Endocrine Abstracts

In recent years, plasma homocysteine (Hcy) level, has been reported to be associated with the vascular complications of diabetes mellitus type 2 (DM2). In patients with DM2, elevated Hcy levels were associated with insulin resistance and nephropathy. The aim of this study was to investigate the association of hyperhomocysteinaemia with micro and macrovascular complications, increased levels of HbA1c and lipid parameters in patients with DM2 in a Macedonian population. 80 DM2 patients were enrolled for the study and were classified into two groups: 30 patients with no associated complications, control, and 50 patients with complications. Homocysteine levels and the other conventional parameters (HbA1c, lipid profile, and microalbuminuria) for identifying complications of DM2 were measured. The Hcy levels were significantly higher in DM2 patients (16.05±6.12 vs 10.44±3.33 micromol/l) compared with control. Significantly elevated homocysteine levels were found in DM2 patients with CAD (P<0.001), neuropathy (P<0.000), retinopathy (P<0.05), high blood pressure (P=0.02) and microalbuminiria (P<0.000) as compared to control subjects. There was a positive correlation between elevated HbA1c (r=0.475) levels and serum LDL-cholesterol (r=0.871) with Hcy concentration in DM2 patients with complication. The results of this study have shown that homocysteine levels were significantly higher in DM2 patients with developed micro-/macro-vascular complications and highly positive correlated with HbA1c and serum LDL-cholesterol, also. Results have shown that hiperhomocysteinemia is risk factor in etiology of vascular complications in DM2 patients.