Endocrine Abstracts

Introduction: Coronary artery calcium (CAC) is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. An association exists between CAC with coronary vascular disease (CVD), Agatston score being an independent predictor of CVD. Including CAC may improve CV risk prediction in addition to conventional risk factors. The AIM of our study was to assess CAC in subjects with prediabetes (preDM) at the beginning of the long term follow-up for occurrence of cardiovascular disease.

Methods: After diagnosing preDM with oral glucose tolerance test and HbA1c, ECG was performed and subjects were evaluated for CVD risk. Score charts were used to calculate the CVD risk. Thereafter, all subjects were appointed for multislice CT to obtain the CAC.

Results: 70 subjects with preDM were screened for CVD. CAC score of 0 was present in 32 subjects. Minimal calcifications with a CAC score of 1–10 AU were present in 12 subjects with pre DM. Moderate calcification of11–100 AU were present in 15 subjects. Nine subjects had significant calcifications with 101–400 AU. Two subjects had a CAC score of 100 AU which meant significant calcifications. Score risk below 2% was present in only 19 subjects, while a score risk of 15% and more was present in 23 subjects. No significant correlation was found between Score charts and CAC. However, a trend of finding more calcifications in those with a 10% and above Score risk was noted.

Conclusion: An approach to risk assessment that combines the traditional risk factor-based paradigm with a more personalized atherosclerosis-imaging model may be appropriate for high risk individuals, such as subjects with pre diabetes.