Endocrine Abstracts

Introduction: According to modern studies, hypercalcemia is associated with an increased risk of urolithiasis, cholelithiasis, gastritis and peptic ulcer.

Objective: To study the prevalence of urolithiasis, cholelithiasis, gastritis and peptic ulcer in patients with hypercalcemia in Minsk-city.

Materials and methods: we studied 1207 people, average age 53.9±17.25 (892 women, 315 men) from 18 to 96 years. Examination: total calcium, total protein, creatinine, ultrasonography, fibrogastroduodenoscopy, an analysis of morbidity.

Results: Hypercalcemia has been found in 31 people, mean age was 58.39±11.6 years. Urolithiasis was detected in 141 cases (in patients with hypercalcemia – in nine cases) cholelithiasis was detected in 107 cases (in patients with hypercalcemia – in ten cases) gastritis was detected in 397 cases (in patients with hypercalcemia – in 21 cases) peptic ulcer was detected in 102 cases (in patients with hypercalcemia – in nine cases).

Significant differences was detected in the prevalence of urolithiasis (χ²=8.54, P=0.0035), cholelithiasis (χ²=19.33, P=0.00001) gastritis (χ²=16.41, P=0.0001) peptic ulcer (χ²=15.69, P=0.0001) in patients with hypercalcemia compared all studied patients.

Conclusion: The results of the study show an increasing risk of urolithiasis, cholelithiasis, gastritis and peptic ulcer in patients with hypercalcemia. The results may indicate an important role of hypercalcemia in the pathogenesis of these diseases.