ECE2017 Eposter Presentations: Calcium and Bone Calcium & Vitamin D metabolism (65 abstracts)
The volume of parathyroid adenoma is related to presurgical PTH and 25OH-D3, but not calcium levels at patients with primary hyperparathyroidism
Cristian Velicescu 1 , Cristina Gatu 1 , Alexandru Grigorovici 1 , Radu Danila 1 , Valentin Munteanu 2 , Voichita Mogos 1 , Carmen Vulpoi 1 , Cristina Preda 1 , Simona Mogos 1 & Dumitru D Branisteanu 1
1University of Medicine and Pharmacy ‘Gr.T.Popa’, Iasi, Romania; 2University of Medicine and Pharmacy ‘Iuliu Hatieganu’, Cluj, Romania.
Aims: We wanted to evaluate the correlations between the volume of the surgically removed parathyroid adenoma and the presurgical metabolic profile of patients diagnosed with primary hyperparathyroidism.
Materials and methods: Prospective multicentric study, enrolling 52 patients with primary hyperparathyroidism from two medical units, proposed for surgery. Serum calcium and PTH were evaluated in all patients before surgery, and 25OH-D3 was measured only in the 33 patients recruited from one of the two surgery departments. Parathyroid volume was measured immediately after excision, using the formula of a rotating ellypsoid. Data were statistically evaluated by using Pearson correlation analysis. Correlations were considered significant at P values lower than 0.05.
Results: We observed a significant correlation between the volume of parathyroid adenomas and presurgical PTH (P<0.001) but not presurgical calcium levels at patients from the two medical units and in the whole group. Twenty-nine out of the 33 patients diagnosed with primary hyperparathyroidism recruited from the first medical unit had 25OH-D3 levels in the range of vitamin D deficiency or insufficiency. 25OH-D3 was not significantly correlated with PTH or calcium levels, but a significant negative correlation was found between the volume of the parathyroid adenoma and serum 25OH-D3 levels (P<0.05).
Conclusion: The volume of parathyroid adenoma seems to be related to presurgical PTH and 25OH-D3, but not calcium level. D hypovitaminosis is frequently found at patients with primary hyperparathyroidism and may contribute to particular disease profiles. Higher PTH and lower 25OH-D3 levels, as well as larger adenomas may be accompanied by increased disease severity, or by a different spectrum of disease complications.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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