ECE2017 Eposter Presentations: Calcium and Bone Bone & Osteoporosis (37 abstracts)
Impact of vitamin D on the bone quality assessed by trabecular bone score in men
Mário Rui Mascarenhas 1, , Ana Paula Barbosa 1, , Nuno Duarte 2 , Ana Wessling 2, , Ana Raquel Coelho Gomes 3 , Carolina Faria 3 , Raquel Paixão 3 , David Barbosa 3 , Catarina Silvestre 3 , José Poupino 2 , Vânia Gomes 3 , Ana Sofia Osório 3 , Francisco Sampaio 2 , Jacinto Monteiro 2 , Didier Hans 4 , Manuel Bicho 1 & Maria João Bugalho 2,
1Endocrinology and Metabolic Diseases, Faculty Medicine of Lisbon, Lisbon, Portugal; 2Fracturary Osteoporosis Outpatient Clinic – Endocrinology, Diabetes and Metabolism Department, Santa University Maria Hospital-Chln, Epe, Lisbon, Portugal; 3Endocrinology, Diabetes and Metabolism Department, Santa University Maria Hospital-Chln, Epe, Lisbon, Portugal; 4Bone Center, Lausanne University Hospital, Lausanne, Switzerland.
Trabecular bone score (TBS) is a recent noninvasive analytical method, based upon DXA images, related to bone microarchitecture or bone quality; together, TBS and DXA may evidence bone strength. Falls and osteoporotic fractures increase with ageing, while both BMD and vitamin D levels slowly decline. Data about the influence of vitamin D on the TBS are scarce.
Aim: To evaluate the influence of the blood vitamin D levels on the TBS in normal men.
Material and methods: The lumbar spine BMD (g/cm2), and TBS (obtained from DXA scans) were evaluated in a group of normal men more than 40 years old. Fasting blood was collected for osteocalcin, 25(OH)D and iPTH measurements. This group was divided in normal, insufficiency and deficiency vitamin D groups (ES Guidelines) and also in normal BMD, low BMD and osteoporosis groups. Total body fat and lean masses were also assessed by DXA. Adequate statistical tests were used (statistical significance P<0.05).
Results: The mean (±S.D.) BMD and TBS of the vitamin D groups are shown in Table 1. Men of the deficiency vitamin D group were the heaviest and had the lowest TBS. Significant relations were detected between the blood 25(OH)D vs. TBS, vs. weight and vs. total fat mass but not vs. BMD.
| Groups Variable | Normal (49.3%) | Insufficiency (37.7%) | Deficiency (13.0%) | P |
| TBS L1-L4 | 1.044 (±0.14) | 1.087 (±0.16) | 1.079(±0.15) | 0.0071 |
| L1-L4 BMD g/cm2 | 1.294 (±0.12) | 1.323 (±0.12) | 1.434 (±0.07) | NSD |
Conclusions: Blood 25(OH)D levels may play an important role on the bone microarchitecture (by TBS) in vitamin D deficient men, as they have worse bone quality. These data suggest that further studies are needed on larger cohort of men and it might be worth to investigate also elderly men with osteomalacia.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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