Endocrine Abstracts

Introduction: In recent years, it is thought that cardiovascular risk is increased in patients with nonfunctional adrenal insidentaloma (NFAI). There are not enough studies in the literature that evaluating this condition in patients with NFAI who don’t have traditional cardiovascular risk factors. The aim of our study is to determine peripheral and central blood pressures and arterial stiffness in patients with NFAI who don’t have traditional risk factors and autonomous cortisol release with pulse wave analysis (PWA) measurement.

Material and methods: In our cross-sectional study, we evaluated 70 participants (35 patients with NFAI and 35 healthy volunteers) without traditional cardiovascular risk factors. All participants were similar in terms of gender, age and body mass index. Measurements of peripheral and central blood pressures and PWA were made with Mobil-O-Graph PWA/ABPM device (I.E.M. GmBH, Stolberg, Germany). Radiological and biochemical data were obtained retrospectively in the NFAI group.

Results: In the NFAI group, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central SBP, central DBP, peripheral vascular resistance, augmentation pressure (AP), augmentation index that corrected based on pulse rate of 75 bpm (Aix@75) and pulse wave velocity (PWV) were significantly higher than control group. We also found that PWA measurements are affected by age and the time from diagnosis to PWA measurement. There was no significant correlations between biochemical parameters and central blood pressures and arterial stiffness parameters in NFAI group.

Conclusion: In patients without traditional cardiovascular risk factors who have NFAI that known as cardiometabolically innocent, both peripheral and central blood pressures and arterial stiffness parameters are affected negatively. These patients are at risk for cardiovascular diseases.