ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Endocrine tumours and neoplasia (50 abstracts)
Descriptive and survival study of 142 cases of gastroenteropancreatic neuroendocrine tumor (GEP-NETs) diagnosed at the Hospital Clínico San Carlos (HCSC)
Rona Penso 1 , Inés Jiménez-Varas 1 , Angela Amengual 1 , Lorea Herraiz 1 , Ane Azkutia 1 , Anna Ortolá 2 , Paz de Miguel 1 & José Angel Díaz 1
1Hospital Clinico San Carlos, Madrid, Spain; 2Hospital Clinico Universitario, Valladolid, Spain.
Introduction: Neuroendocrine tumors (NETs) constitute a very heterogeneous group of rare neoplasms, although their incidence has increased in recent years. We describe its evolution and survival.
Methods: Retrospective study. All patients with histopathological diagnosis of GEP-NETs performed at the HCSC between 2000 and 2016 were selected, data from the medical history were included. Statistical analysis were done with SPSS.
Results: One hundred and forty-two patients, 54.9% male, mean age 60.2 years (S.D. 19.7). The median follow-up time was 3.3 years (IR: 0.78–6.33). The most frequent locations were pancreatic (28.2%) and rectal (16.2%). The tumor stage was: I 47.2%, II 4.9%, III 13.4%, IV 34.5%. The initial stage (IS) presented positive correlation with the degree of differentiation (DD) (Cramer’s V 0.46, P <0.05) and with levels of Chromogranin A (Cramer’s V 0.37, P <0.05). 12% had progression and 64% died during follow-up (72% due to tumor). Overall survival at 5 years was 69 and 53% at 10 years. There were significant differences in survival according to location, with gallbladder and colon being the lowest (0 and 38% at 5 years, respectively). DD, IS and sex were also associated with survival (at 10 years: G1 95% vs G3 14.3% P<0.01, stage I 91% vs IV 28% P<0.01, median males 7.5 years vs 16.9 in females P 0.018). These differences were maintained after multivariate analysis in the case of DD and IS.
In stage IV survival was modified according to surgical treatment (operated median 5.9 years vs non-operated 0.64 years, P<0.01).
Conclusion: In our sample the overall mortality was high, despite having a low rate of progression. DD and IS were determinants of survival. In advanced stages surgical treatment improves survival significantly.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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