ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Endocrine tumours and neoplasia (50 abstracts)
Large intestinal metaplasia is a precancerous lesion present in patients with gastric neuroendocrine neoplasms type 1
Georgios Boutzios 1 , Krystallenia Alexandraki 1 , Vassiliki Mavroeidi 1 , Eleni Koukoulioti 2 , Ioannis Papanikolaou 2 & Gregory Kaltsas 1
1Endocrine Unit, Department of Pathophysiology, Medical School, National and Kapodistrian University, Laikon University General Hospital, Athens, Greece; 2Hepatogastroenterology Unit, Second Department of Internal Medicine - Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University, Attikon University Gen, Athens, Greece.
Background: Intestinal metaplasia (IM) of the gastric mucosa is a relatively frequent precancerous lesion. The aim of the study was to assess the prevalence and the kind of IM and also to find parameters that could predict the presence of IM in gastric neuroendocrine neoplasms type 1 (GNEN1).
Methods: Fifty-nine (45 females) patients with GNEN1 were retrospectively studied. All patients included in the study had positive parietal-cell antibodies. All patients underwent a gastroscopy with multiple biopsies. Chromogranin A, gastrin, vitamin B12, folate and ferritin levels were also assessed.
Results: The mean age and follow up were 54.14±13.62 years and 67.66±48.9 months, respectively. At diagnosis, chromogranin A, gastrin, vitamin B12, folate and ferritin levels were: 277.54±173.54 ng/ml (<98), 896.18±818.98 pg/ml (<110), 395.43±488.18 pg/ml (300–960), 12±11.36 ng/ml (2–20) and 58.02±75.08 ng/ml (20–350), respectively. Intestinal metaplasia appeared in 48 patients (81.35%) with GNEN1; 41 (85.5%) had large IM, 1 (2%) had small and 6 (12.5%) had both small and large IM. In univariate regression analysis, only mean follow-up from the parameters studied (age at diagnosis, gender, biochemical markers) predicted the presence of intestinal metaplasia (OR: 0.979; 95%CI: 0.961–0.997, P=0.021).
Conclusion: Our study showed a high prevalence of large IM in GNEN1. Mean follow up predicted IM presence. Further clinical studies are required to determine which parameters predict the presence of IM in patients with GNEN1.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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