ECE2017 Eposter Presentations: Adrenal and Neuroendocrine Tumours Adrenal cortex (to include Cushing's) (86 abstracts)
Primary hyperparathyroidism associated with Cushing syndrome and primary hyperaldosteronism
Fatma Mnif , Hamza Elfekih , Mouna Elleuch , Faten Hadjkacem , Dorra Ghorbel , Nabila Rekik , Mouna Ammar , Mouna Mnif & Mohamed Abid
Hedi-Chaker University Hospital, Sfax, Sfax, Tunisia.
Introduction: The simultaneous occurrence in the same patient of more than one endocrinological condition is rare and was described in the multiple endocrine neoplasia (MEN). Here, we report a patient with an unusual combination of primary-hyperparathyroidism, papillary thyroid microcarcinoma, primary-hyperaldosteronism and ACTH-independent Cushing’s syndrome.
Case description: A 54-year-old women with a primary-hyperparathyroidism was admitted to our hospital to undergo a parathyroidectomy for a single adenoma and total thyroidectomy for suspicious nodules in which one of it was confirmed histopathologically to be a 3 mm papillary thyroid microcarcinoma. An exploration of a resistant hypertension associated with hypokalaemia was done and the co-secretion excess of aldosterone (aldosterone-renin ratio >23 ng/ng twice) and cortisol (negative overnight and low-dose Dexamethasone suppression with low ACTH level) was confirmed with an abdominal CT-scan showing a 19 mm left adrenal adenoma. The patient has also multiple lipomas.
Conclusion: The multiple endocrine hypersecretion exists and the MEN1 should be considered since there is a considerable number of atypical MEN1 syndrome thus the DNA testing is scheduled.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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