Endocrine Abstracts

Psychological symptoms including aggression, confusion, irritation, anxiety and depression have been observed clinically in patients with carcinoid syndrome. It has been suggested that vasoactive-hormone secretion is involved in provoking psychological symptoms. The objective of this qualitative study is to explore the presence and experience of specific psychological symptoms in carcinoid syndrome. Nine patients with carcinoid syndrome and psychological issues currently or within past year were recruited from two NET specialist centres. They participated in qualitative interviews focusing on their previous and current experiences of physical and psychological symptoms. Patients experienced various psychological symptoms including anxiety, agitation and irritability and occasional low mood, mood swings and mild aggressive tendency. The unpredictable nature of physical distress from physical symptoms resulted in psychological symptoms. Although many patients had anxiety from cancer-related issues, there was a link between anxiety and flushing in a minority. Patients with positive outlook maintained good mood and were better at coping but no evidence to suggest it affected anxiety-related flushing, agitation or irritability. Cancer-related issues, impacts of physical symptoms, external issues and vasoactive-hormones are all implicated in producing psychological symptoms in carcinoid syndrome. By identifying issues and contributing factors, patients at risk can be monitored and psychological support provided.