SFEBES2016 Poster Presentations Neuroendocrinology and pituitary (34 abstracts)
The role of kisspeptin in the medial amygdala on male sexual behaviour in rats
Rebecca Gresham , Shengyun Li Li , Daniel Adekunbi , Minghan Hu , Xiao Feng Li Li & Kevin O’Byrne
King’s College London, London, UK.
The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesized that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats. This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response. When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections. We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites. We conclude that Kiss1 has a role in male sexual behavior, which is specific to the MePD.
Volume 44
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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