Endocrine Abstracts

Thyroid hormone (TH) actions and metabolism are intracellular events that require the transport of TH across the plasma membrane. This process is facilitated by TH transporters of which the monocarboxylate transporter 8 (MCT8), encoded by the Slc16a2 gene, has been most intensively analyzed. In humans, inactivating mutations in the X-linked MCT8 gene are associated with a severe form of psychomotor retardation in combination with abnormal serum TH parameters. The clin...

Thyroid hormone (TH) is a major determinant of muscle physiology, and thyroid dysfunctions are leading causes of many myopathies. Precise control of thyroid hormone-dependent transcription is required by multiple cell system, including muscle stem cells, but how this is achieved is still largely unknown. Intracellular TH concentration is determined by a metabolic balance between the activating and inactivating deiodinase enzymes, D2 and D3. In functional combinations, these re...

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