Endocrine Abstracts

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Several differences have been observed in thyroid function parameters between older and younger individuals. Notably, circulating thyroid stimulating hormone (TSH) levels gradually increase with age, a shift shown to extend to extremely high ages. While clinically abnormal thyroid function parameters have been consistently associated with ill health, the mechanisms underlying mild age-related variations in circulating levels of TSH and thyroid hormones and their health consequ...

Chronic stress or excess glucocorticoids may promote brain ageing and cognitive decline. Elevated blood cortisol levels or increased sensitivity to cortisol’s action in brain cells play a crucial role in the development of age-dependent memory deficits. It is now recognized that the concentration of glucocorticoids within specific tissues including brain are derived not just from blood hormone levels but also from the local regeneration of active glucocorticoids by 11&#94...