SFEBES2016 Poster Presentations Reproduction (33 abstracts)
The relation of liver enzymes and insulin resistance in women with polycystic ovary syndrome (PCOS)
Djuro Macut 1 , Ivana Bozic-Antic 1 , Konstantinos Tziomalos 2 , Jelica Bjekic-Macut 3 , Dusan Ilic 1 , Danijela Vojnovic-Milutinovic 4 , Olivera Stanojlovic 5 & Dimitrios Panidis 2
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia; 2Department of Medicine, University of Thessaloniki, Thessaloniki, Greece; 3CHC Bezanijska Kosa, Belgrade, Serbia; 4IBISS, University of Belgrade, Belgrade, Serbia; 5Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: There is a link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). Here, we analyzed transaminazes and their relation to insulin resistance (IR) in PCOS women.
Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria (age:25.6±5.9 years, BMI: 30.6±6.9 kg/m2), and 125 BMI-matched healthy controls (age: 31.4±5.3 years, BMI: 29.6±6.8 kg/m2). IR was evaluated using HOMA-IR cut-off 2.5. Subjects were divided into: PCOS-IR (N=384), PCOS-nonIR (N=216), Controls-IR (N=53) and Controls-nonIR (N=72). Analyses were age and BMI adjusted.
Results: The highest AST was found in PCOS-IR and significantly differed in comparison to PCOS-nonIR (20.75±8.31 vs 17.99±5.04 U/l, respectively, P<0.05). There was no difference in AST between Controls-IR and Controls-nonIR (18.96±6.66 vs 18.38±5.63 U/l, respectively, P>0.05). ALT was highest in PCOS-IR and significantly differed from PCOS-nonIR (25.36±16.21 vs 18.59±10.08 U/l, respectively, P<0.05), while ALT levels were the same in Controls-IR compared to Controls-nonIR (24.60±12.97 vs 19.97±10.94 U/l, respectively, P>0.05). In PCOS HOMA-IR correlated with both AST (ρ=0.202, P<0.001) and ALT (ρ=0.315, P<0.001) while in Controls only with ALT (ρ=0.254, P=0.004).
Conclusions: Although our PCOS women had normal values of liver enzymes, they were higher in comparison to controls. It seems that IR could additionally contribute to the disturbance of liver enzymes in PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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