SFEBES2016 Poster Presentations Bone and Calcium (20 abstracts)
The impact of primary hyperparathyroidism and its treatment on bone mineral density, bone mineral parameters, insulin resistance, body composition and quality of life – A prospective pilot study from India
Thomas V Paul , Shrinath Shetty , Nitin Kapoor , Sahana Shetty , M J Paul , Deepak Abraham , Pooja Ramakant , Joseph Dian & Nihal Thomas
Christian Medical College, Vellore, Tamil Nadu, India.
Aims: To study changes in bone mineral density (BMD), bone mineral parameters, metabolic profile, body composition and quality of life at base line and 6 months following parathyroidectomy, in subjects with primary hyperparathyroidism (PHPT).
Material and methods: This prospective study was conducted over 18 months with first 12 months of recruitment and next 6 months for follow-up. Sixty-eight patients with PHPT who underwent surgery were compared with 117 age, BMI and sex-matched controls. BMD, total fat mass and visceral adipose tissue (VAT) were assessed by a DXA scan at baseline and after 6 months. Other assessment included bone mineral parameters and bone turnover markers (BTMs). Thirty patients completed 6 months follow-up.
Results: Among the 68 patients (48 males, 20 females) with PHPT, the most common presentation was renal calculi (61.7%) followed by bony involvement (29.4%). There was a significant improvement in QoL and BMD on follow-up (at all sites) along with normalization of bone biochemistry and a decrease in BTMs (P<0.05). There was a significant increase in BMI, total fat mass and VAT (P<0.05). There was a non-significant increase in HOMA –IR.
Conclusion: There was a significant improvement in bone health and QoL following curative parathyroidectomy. A significant increase noted in BMI and VAT mass on follow-up needs to be further studied with regards to definite clinical outcomes like diabetes mellitus.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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