Endocrine Abstracts

Primary hyperparathyroidism (PHPT) has become more prevalent as routine screening for serum calcium became more widespread. The current prevalence of PHPT is about 0.5–1% and possibly higher. The majority of patients are asymptomatic or have relatively subtle symptoms. NIH criteria for surgery are mainly based on patient symptoms and/or signs of end-organ damage, and the majority of patients do not fulfil these criteria. However it has become apparent that patients not fu...

Hypogonadotrophic hypogonadism (HH) in males is defined both biochemically – low serum testosterone (T) level with LH+FSH levels in or below the lower half of the reference range – and clinically. ie. the person is actually hypogonadal. This clinical criterion is crucial for an accurate diagnosis adult-onset HH in men, because biochemical features are common to other scenarios for which T treatment is presently not indicated. These include afternoon-, or non...

Adrenal incidentalomas (AI) found on axial imaging are common. In ages <20 y the prevalence is <1%, but this increases around 10% of the population aged 70 y. Depending on definitions anything between 10–40% of these tumours exhibit low-grade cortisol excess, but patients are without the classic features of Cushing’s syndrome. This equates to 1–4% of the ageing population.Independent studies from our own group and others have demon...