WCTD2016 Abstract Topics Cardiovascular Outcome Studies (12 abstracts)
Bromocriptine shifts the blood pressure circadian rhythm in type 2 DM and stage 4 of chronic kidney disease patients: A post hoc study
Oliva Mejia-Rodriguez 1, , Humberto Ruiz-Vega 2 , Cleto Alvarez-Aguilar 3 , Guillermo Ceballos-Reyes 4 , Maria Eugenia Galván-Plata 5 & Ramon Paniagua 5
1Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Mexico; 2División de Estudios de Posgrado, Facultad de Ciencias Medicas y Biologicas Dr. Ignacio Chávez. UMSNH, Mexico; 3Coordinación Auxiliar de Investigación en salud, Instituto Mexicano del Seguro Social, Mexico; 4Escuela Superior de Meidicina, Instituto Politecnico Nacional, Mexico; 5Coordinacion de Investigacion en Salud, Instituto Mexicano del Seguro Social, Mexico.
Background: Type 2 DM and chronic renal disease CKD are conditions associated with severe hypertension, loss of the blood pressure circadian rhythm (CR) and sympathetic nervous system (SNS) hyperactivity, suggesting a deficient dopaminergic modulation that could be reversed with dopamine agonists such as bromocriptine (BEC).
Objective: The objective of this study was to evaluate the effect of bromocriptine in the blood pressure CR in patients with type 2 DM and stage IV of CKD.
Material and methods: The data were obtained from a previous controlled clinical trial. 28 patients were included. 14 received 2.5 mg BEC tablets three times a day during six months and 14 received placebo (PBO). Blood pressure was measured by 24 h ambulatory blood pressure monitoring). The CR was identified by the method of Cosinor. The CR was characterized by the equation PA = M+ acos (2π/T t+φ), with the following parameters: 1) phase; 2) mesor (M), 24 h mean blood pressure; 3) amplitude (A) and; 4) time period (T=24 h, 12 h). Comparisons time to time were performed with student T test. A general linear model was used to analyzed the differences between and intragroup.
Results: Daytime and nighttime blood pressure improved significantly in the BEC group compared to PBO. The mesor mean arterial pressure decreased in the BEC group and increased in the PBO group. 100.9 mmHg (BEC) vs 106.24 mmHG (PBO) P 0.05.
Conclusions: BEC decreased blood pressure, increased and shifted the amplitude to the early hours of the morning.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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