Endocrine Abstracts

Recent results from us and others have shown that concentrations of sex steroids in serum/circulation do not always reflect their intra-tissue levels in hormone-dependent tissues. This proposes that sex steroid metabolism plays a key role in determining the final concentration of active sex steroids in their target tissues. According to the current knowledge, members of three enzyme families, namely cytochrome P450 (CYP), aldo-keto reductase (AKR) and short-chain dehydrogenase...

Metabolic alterations have long been known to occur in the transition to prostate cancer, from alterations in central metabolism to lipid metabolism and local steroid biosynthesis. However the upstream events that lead to these alterations have not been comprehensively assessed. In this presentation I will draw together genomic, epigenomic and transcriptomic analysis, together with metabolic profiling. Overlaying the effects of androgen signaling on these pathways and metaboli...