Endocrine Abstracts

The international cancer genome projects have provided comprehensive catalogs of molecular alterations in cancer and often led to new molecular tumor stratification. Furthermore, genome sequencing has provided an improved understanding of the mutational processes underlying cancer formation and progression. Interestingly, mutations in genes coding for chromosomal maintenance, DNA methylation and histone modification are frequent in many tumor entities. These epigenomic changes...

Androgens play an important role in the development and the maintenance of the normal prostate gland. Androgen Receptor (AR) signaling is also critical during the initiation and development of prostate cancer that may present with a range of genomic lesions possibly due to DNA repair defects. We first noted a significant correspondence between DNA breakpoints and AR binding sites supporting the inter-related action that hormone regulation plays a role on genomic events. We hyp...