Endocrine Abstracts

To clarify the risks associated with subclinical thyroid dysfunction, we built in 2008 the Thyroid Studies Collaboration and collected into individual participant data from 70 000 participants from 17 prospective cohorts. We first clarified the risks of coronary heart disease, heart failure and mortality and assessed the contribution of autoimmunity on the risks of cardiovascular diseases. We also assessed the risk of stroke associated with subclinical thyroid dysfunction. Then, we extended our study to assess the risk of fractures associated with subclinical thyroid dysfunction, as well as the impact on bone mineral density. We also explored what the most appropriate TSH levels in the euthyroid range, analysing the risks of clinical outcomes within the normal range. Results of all these studies will be presented at this session. We were able to clarify these risks, which could not be adequately addressed in previous study-level meta-analyses or in single cohorts performed in a more limited age group or without TSH stratification.