ECE2016 Oral Communications Obesity (5 abstracts)
Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on circulating pro-neurotensin in the Diet, Obesity, and Genes (DiOGenes) Study: a randomized, controlled trial
Natalia Rudovich 1, , Wolfgang Bernigau 1 , Olga Pivovarova 1, , Martin Osterhoff 1, , Andrea Sparwasser 3 , Andreas Bergmann 3 , Joachim Struck 3 , Marleen A van Baak 4 , Susan A Jebb 5 , Angeliki Papadaki 6 , J Alfredo Martinez 7 , Teodora Handjieva-Darlenska 8 , Marie Kunesova 9 , Jorg Hager 10 , Armand Valsesia 10 , Nathalie Viguerie 11 , Dominique Langin 11 , Arne Astrup 12 , Wim H M Saris 4 & Andreas F H Pfeiffer 1,
1German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; 2Charite’ Universitätsmedizin, Berlin, Germany; 3Sphingotec GmbH, Berlin, Germany; 4NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands; 5Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK; 6Department of Social Medicine, Preventive Medicine, and Nutrition Clinic, University of Crete, Heraklion, Greece; 7Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain; 8Department of Human Nutrition, Dietetics, and Metabolic Diseases, National Transport Hospital, Sofia, Bulgaria; 9Obesity Management Centre, Institute of Endocrinology, Prague, Czech Republic; 10Nestlé Institute of Health Sciences SA, Lausanne, Switzerland; 11Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Inserm, Paul Sabatier University, Toulouse, France; 12Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Aims: Elevated levels of neurotensin (NT), a neurotransmitter and postprandial secreted intestinal hormone, are associated with an increased risk of diabetes, cardiovascular disease and breast cancer. Here we studied the regulation of circulating pro-NT (a stable NT precursor fragment) by weight loss and dietary interventions.
Methods: DiOGenes is a pan-European controlled dietary intervention study in overweight adults who first lost body weight on an 8-week low-calorie diet (800 kcal/day) and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high (HPI) or low (LPI) protein or high (HGI) or low (LGI) glycemic index in 4 combinations or control.
Results: Weight loss (11.2±3.5 kg; P<0.001) reduced pro-NT (202.6±117.8 pmol/l to 186.5±96.1 pmol/l; P=0.007) and was similar in both genders. During the weight maintenance period, pro-NT showed a trend to increase among both genders assigned to HGI diets (m/w; P=0.11 and P=0.08), and no changes of pro-NT in LGI diets. LPI increased pro-NT levels in male subjects (P=0.003), and no changes in HPI. In women, both HPI and LPI had no effects on circulating pro-NT. Additionally we divided subjects in three groups depended on baseline pro-NT values. Subjects with “low-proNT” (values <25th percentile) showed an increase of pro-NT after weight-loss followed by small decrease in the 26-week weight maintenance period. In contrast, the subjects with “high-proNT” (values >75th percentile) showed an opposite response. No differences were observed in anthropometrical or biochemical parameters between three quartiles at baseline. “Low-proNT” stratum showed lower weight under both LGI-diets (P=0.046).
Discussion: Our data suggest that a pro-NT reduction after weight loss is better maintained by LGI and HPI diets. Weight loss inversely regulates circulating pro-NT suggesting an intrinsic physiological phenomenon that possibly reflects the central regulation of the weight maintenance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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