ECE2016 Guided Posters Adrenal (2) (10 abstracts)
Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome
Marta Kialka 1 , Tomasz Milewicz 1 , Agnieszka Ociepka 2 , Magdalena Krzyczkowska-Sendrakowska 1 & Ewa Stochmal 2
1Department of Gynecological Endocrinology, Jagiellonian University, Medical College, Cracow, Poland; 2Department of Endocrinology, Jagiellonian University, Medical College, Cracow, Poland.
Introduction: The aim of our study was to assess the morning and evening cortisol plasma levels in women with polycystic ovary syndrome (PCOS).
Material and method: 95 patients gave their informed consent to participate in the study and were divided into two groups. Group A consisted of 40 PCOS patients and group B consisted of 55 women without features of PCOS. Between day 5 and 8 of the menstrual cycle, morning (0700 h), fasting blood samples were taken for the assessment of LH, FSH, estradiol (E2), cortisol, prolactin, TSH, testosterone and DHEAS. Evening (1700 h) blood samples were also taken for the evaluation of plasma cortisol level.
Results: There were no differences in mean age, BMI, FSH, SHBG, PRL, E2 and TSH levels between group A and group B. Mean plasma LH level was higher in group A compared to group B (10.7±6.8 IU/l vs 6.6±4.5 IU/l, P<0.02). Mean plasma testosterone and DHEAS levels were also higher in PCOS patients (3.8±0.6 nmol/l vs 1.63±0.6 nmol/l; 427.7±162.9 vs 236.6±97.8 resp, P<0.001). Mean evening plasma cortisol level was higher in PCOS patients (11.8±4.1 μg/dl vs 7.4±5.0 μg/dl, P<0.02). Mean morning plasma cortisol levels did not differ between groups.
Conclusion: PCOS women showed the increased plasma cortisol level with impacted diurnal secretion rate.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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