ECE2016 Guided Posters Thyroid Cancer (10 abstracts)
Prognostic factors for tumor invasiveness in papillary thyroid microcarcinomas
Antonios Polymeris 1 , Maria Mizamtsidi 2 , Alexis Travlos 1 , Georgios Katsoulis 1 , Fotini Dimitropoulou 2 , Alexandros Dermentzoglou 2 , Nikolaos Kalogeris 2 , Constantinos Tzioras 2 & Andromachi Vryonidou 2
1Department of Endocrinology, Diabetes and Metabolism, Alexandra Hospital, Athens, Greece; 2Department of Endocrinology, Diabetes and Metabolism, Korgialenio-Benakio, Hellenic Red Cross Hospital, Athens, Greece.
Introduction: Papillary thyroid microcarcinomas (PTMC) are usually considered low-risk tumors with favorable prognosis. However, a small percentage behaves aggressively and controversies exist for various prognostic factors. The aim of this study was to evaluate demographic and tumor specific characteristics related to PTMC invasiveness.
Patients – methods: This is a retrospective study of 510 thyroidectomized patients with PTMC who were treated in two Endocrine Departments of Athens, between 1995 and 2015. All data were obtained from the patients’ medical records. Most of the patients underwent thyroidectomy for multinodular goiter (70.5%) and the rest for a single nodule (29.5%). Demographic and tumor specific characteristics were evaluated.
Results: Patients’ mean age was 46.4±12.9 years. Women were more frequently affected (84.5%) than men. Pathology of the tumors revealed classic papillary subtype in 55.4% of the patients, follicular variant in 35.4%, tall cell variant in 2.7%, columnar variant in 0.2% and combinations less frequently. Regarding tumor size, the median diameter was 8 mm (0.01–15). Patients were divided in three subgroups regarding maximum tumor size as follows: 0–5 mm (47%), 6–10 mm (46.6%) και 11–15 mm (6.4%). Multifocality was observed in 34.9% of the patients, while 3.4% had PTMC in more than three foci. The median diameter of the sum of all foci was 8 mm (range 1–43 mm). Thyroid capsule invasion was present in 25% of the patients, lymph node invasion in 8.7%, muscle or fat tissue invasion in 6.4% and vessel invasion in 1.4%. Multiple regression analysis revealed that PTMC variants, was the only independent predictive factor for invasiveness.
Conclusions: Tumor subtype seems to be the most powerful prognostic factor for PTMCs aggressiveness, as it is expressed by invasion of thyroid capsule or surrounding tissues.
Volume 41
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Endocrine Abstracts
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