ECE2016 Guided Posters Adrenal (1) (10 abstracts)
Congenital adrenal hyperplasia (CAH) in adulthood
Jana Vrbikova 1 , Zdenek Frysak 2 , Jan Cap 3 , Michal Krcma 4 , Renata Cifkova 5 & Vera Lanska 6
1Institute of Endocrinology, Prague, Czech Republic; 2IIIrd Clinic of Internal Medicine FN Olomouc, Olomouc, Czech Republic; 3IVth Clinic of Internal Medicine FN Hradec Králové, Hradec Králové, Czech Republic; 4Ist Clinic of Internal Medicine FN Plzeň, Plzen, Czech Republic; 5Center of Cardiovascular Prevention 1.LF and TN Praha, Prague, Czech Republic; 6IKEM, Prague, Czech Republic.
Background and aim: Up to now, there is paucity of studies concerning health status in adults with congenital adrenal hyperplasia (CAH). We aimed to examine a group of adult CAH patients from different Czech centers.
Methods: Serum lipids, glucose, blood pressure and anhtropometrics were compared in 31 males and 71 females with CAH 21-hydroxylase deficiency and in healthy population from Czech post-MONICA study (1% random population sample).
Výsledky: CAH males were significantly smaller (161.4 (1.3) vs 178.5 (0.2) cm; P=0.0001), had lower total (4.6 (0.23) vs 5.2 (0.02) mmol/l; P=0.009) a and higher HDL-cholesterol (1.5 (0.07) vs. 1.30 (0.009) mmol/l; P=0.004) and lower triglycerides (1.16 (0.19) vs 1.6 (0.02) mmol/l, P=0.02) than healthy males. Dyslipidemia (total cholesterol ≥ 5 or LDL cholesterol ≥3 mmol/) was present in 24% of them.
Women with CAH were significantly smaller (154.9 (0.8) vs 165.7 (0.2) cm; P=0.0001), had higher BMI (28.5 (0.7) vs 26.5 (0.14) kg/m2 P=0.005), higher total (5.49 (0.13) vs 5.16 (0.02) mmol/l; P=0.02) and higher HDL-cholesterol (1.8(0.06) vs 1.63 (0.009) mmol/l; P=0.002) than healthy females. Total cholesterol ≥5 mmol/l was present in 56% of them and LDL-cholesterol ≥3 mmol/l in 41%.
Osteopenia/osteoporosis was present in 35% (5/14) males and in 31% (8/26) females.
Conclusion: CAH males do not have impaired cardiovascular risk factors. In CAH women, dyslipidemia was present in 56 and obesity was more common than in healthy population.
Supported by Czech ministry of health EU, 00023761.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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