Endocrine Abstracts

Introduction: The Nephron is a known target organ of the Growth Hormone/Insulin-like factor-1 axis. They influence glomerular and tubular function having an important physiological role in water and electrolyte balance, especially in Acromegaly. The aim of the study was to investigate renal function in acromegalic patients during active disease and remission and evaluate hormonal impact on renal function markers.

Methods: A retrospective, longitudinal, observational analysis was performed regarding 52 acromegalic patients. Variables such as creatinine, glomerular filtration rate (GFR), IGF1/GH and the remainder pituitary hormones were evaluated. Descriptive statistical methods were used and the results are presented as mean and standard deviation. Pearson correlations and student T-test were used to analyze numerical data.

Results: 52 acromegalic patients (69.2% females) with a mean age of 57 years were eligible to the study. The underlying etiology was a pituitary macroadenoma in 78.9% and 19.2% were treated with Radiotherapy. Disease control was achieved in 71.2%. Statistical significant correlations were found between IGF-1 and creatinine and eGFR (P 0.001 and 0.003 respectively). Patients in remission had a lower mean eGFR (79 vs 89 mL/min/1.73 m²). Degree of elevation of IGF1 from the upper normal range (expressed in %) was correlated with eGFR, creatinine and metabolic parameters (Fasting blood glucose and glycated hemoglobin) with statistical significance.

Conclusion: The current study demonstrates consistently a possible positive correlation between IGF1/GH axis and renal function markers. Despite being a retrospective study, the sample size may further support the relevance of the GH/IGF1-renal axis in Acromegaly.