Endocrine Abstracts

Introduction and aims: Numerous studies in recent years have confirmed the existence of a link between endothelial dysfunction and vascular diseases, and lifestyle factors such as obesity, sedentary lifestyle and smoking.

Methods: We examined 108 patients with obesity (90 women and 18 men, mean age 54.62±0.4 years). All patients underwent clinical and laboratory examination. Vasomotor endothelial function was evaluated by reactive hyperemia using ultrasonic device Aloka SSd-5500 located on the procedure Celermajer and collaborators. According to the formula counts% increase in vessel diameter: endothelium-dependent vasodilation (EDVD) =((Diameter of the brachial artery after reactive hyperemia - the diameter of the brachial artery source) / diameter of the brachial artery source) × 100%.

Results: The level of smoking patients EDVD significantly higher normal values - the percentage of increase was 6.81±1.08%, while non-smokers - 12.28±1.08%. Patients prone to smoking, level of MAU exceeded the normal value amounted to 26.3±8.22 g/l and in non-smokers - 17.64±1.25 mg/l. Homocysteine levels in non-smokers was 11.47±0.74 mol/l, in smokers - 13.72±0.60 mkml/l.

Conclusions: Obese patients prone to smoking have a sign of endothelial dysfunction.