ECE2016 Eposter Presentations Adrenal cortex (to include Cushing's) (85 abstracts)
Serum but not salivary cortisol levels are influenced by daily glycemic oscillations in type 2 diabetes
Giuseppe Bellastella 1 , Maria Ida Maiorino 1 , Annamaria De Bellis 2 , Lorenzo Scappaticcio 1 , Katherine Esposito 3 & Dario Giugliano 1
1Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy; 2Endocrinology and Metabolic Diseases Unit, Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Naples, Italy; 3Department of Clinical and Experimental Medicine, Naples, Italy.
Diurnal salivary and plasma cortisol variations are considered valid expression of circadian cortisol rhythmicity. The aim of this study was to assess the reliability of salivary and plasma cortisol evaluating if glycemia and glycemic oscillations may interfere with their concentration.
Methods: Forty-seven type 2 diabetic patients and 31 controls were studied for glycemic profile and diurnal salivary and plasma cortisol variations on two contemporary samples taken at 0800 and 2300 h (Late Night, LN). Glucose variability was evaluated in diabetic patients by considering the standard deviation of blood glucose (BGSD) readings, by calculating the mean amplitude of glycemic excursions (MAGEs) and continuous overlapping net glycemic action (CONGA).
Results: A significant correlation between LN serum cortisol and morning fasting glycemia (r=0.78; P=0.004) was observed in T2DM group but not in the control group (r=0.09; P=0.74). While LN serum cortisol significantly correlated with CONGA in diabetic patients (r=0.50; P<0.001), LN salivary cortisol did not correlate with any indices of glucose variability. Moreover, a highly significant correlation between LN salivary and LN serum cortisol concentrations was found in control group (r=0.80; P<0.001) but not in diabetic patients (r=0.07; P=0.62).
Conclusions: This study shows for the first time that late night salivary cortisol may give more information than late night plasma cortisol on the dynamic of adrenal function of type 2 diabetic patients, as it is not significantly influenced by glycemic variations.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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