ECE2016 Eposter Presentations Obesity (69 abstracts)
Decrease in arterial stiffness (AS) in morbidly obese (MO) patients after bariatric surgery (BS): Relationship with obstructive sleep apnoea (OSA), anthropometric parameters and low-grade inflammation (LGI)
Assumpta Caixàs 1 , Raquel Tirado 1 , Laura Vigil 2 , María José Masdeu 2 , María Villaplana 2 , Alexis Luna 3 , Pere Rebassa 3 , Marta Hurtado 1 , Rocío Pareja 1 , Belen Pons 1 & Mercedes Rigla 1
1Endocrinology and Nutrition Departament, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí- UAB Universitat Autònoma de Barcelona, Campus d’Excel lència Internaci, Sabadell, Spain; 2Pneumology Department Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí- UAB Universitat Autònoma de Barcelona, Campus d’Excel lència Internacional 08193 Bellater, Sabadell, Spain; 3Surgery Department, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí- UAB Universitat Autònoma de Barcelona, Campus d’Excel lència Internacional 08193 Bellaterra, Bellatera-Sabadell, Spain.
Materials and methods: We studied 30 MO patients with OSA without Continuous Positive Airway Pressure (CPAP) treatment, before and one year after surgery. All patients underwent overnight conventional polisomnography (CE-Series Compumedics, Victoria, Australia). Sleeve gastrectomy or Roux-en-Y gastric bypass were performed according to the local protocol. To asses AS, augmentation index adjusted for heart rate (IAx@75) was obtained by applanation tonometry (Sphygmocor® versión 7.0 AtCor Medical, Sidney, Australia). To assess LGI, TNFα, IL-6, IL1β, PCR and adiponectin levels were measured (Milliplex Catalog, Merck Millipore, Madrid). Average blood pressure (ABP), BMI and % body fat (%BF) by bioelectrical impedance (TANITA) were also measured. For statistical analysis SPSS version 19 was used.
Results: AS, ABP and LGI decreased after BS (IA@75 22.6±11.5 vs 19.0±12.8, ABP 102.3±9.02 vs 95.1±8.97 mmHg, TNFα 3.07±1.89 vs 2.47±1.3 pg/mL, IL6 0.64±0.87 vs 0.45±0.76 pg/mL) and adiponectin increased (15.3±8.83 vs 30.4±14.7 μg/mL), P<0.05 before vs after surgery. IA@75 decline correlated with BMI and %BF improvement (r=0.532, P=0.002; r=0.491, P=0.006, respectively) but not with LGI improvement. IA@75 decline was predicted by Apnoea Hypopnoea index (beta=−0.489, P=0.009) and %BF (beta=0.426, P=0.021), before surgery.
Conclusion: In patients with MO and OSA, the less OSA severity and the more %BF before surgery, the more AS improvement achieved after BS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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