ECE2016 Eposter Presentations Obesity (69 abstracts)
Mean platelet volume in a patient with celiac disease: the relationship between metabolic syndrome, impaired fasting glucose and cardiovascular risk
Handan Cipil 1 , Idris Baydar 2 , Konca Altinkaynak 3 , Esra Ademoglu 4 , Esra Laloglu 5 , Murat Filiz 2 , Ahmet Veli Sanibas 2 , Faruk Yildiz 2 , Hakan Sevimli 2 , Muttalip Arslan 2 , Senay Arikan 6 & Ayse Carlioglu 7
1Selcuk University Faculty of Medicine Department of Hematology, Konya, Turkey; 2Erzurum Regional Training and Research Hospital Department of İnternal Medicine, Erzurum, Turkey; 3Erzurum Regional Training and Research Hospital Department of Biochemistry, Erzurum, Turkey; 4Bolu University Faculty of Medicine, Bolu, Turkey; 5Erzurum Laboratory of Public Health, Erzurum, Turkey; 6Kirikkale University Faculty of Medicine Department of Department of Endocrinology and Metabolism, Kirikkale, Turkey; 7Erzurum Regional Training and Research Hospital Department of Endocrinology and Metabolism, Erzurum, Turkey.
Celiac Disease (CD) is a chronic inflammatory disorder and requires life-long treatment and follow-up. Mean platelet volume (MPV), determinant of platelet function, is an independent risk factor for cardiovascular disease (CVD). Metabolic syndrome (MS) is a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose deposition and function. It is a risk factor for coronary heart disease, as well as for diabetes, fatty liver, and several cancers.
The aim of this study was to evaluate MPV and RDW values in CD patients and the relationships between MPV, RDW, MS, impaired fasting glucose (IFG) and cardiovascular risk.
Thirty-six CD patients (mean age 29.28±13.35 years) and 30 healthy control individuals (mean age 31.56±10.54 years) were included in the study. CD patients adhered to a strict gluten-free diet and at least one year are diagnosed. The controls were matched to cases according to age, gender and BMI. A diagnosis of CD was established by positive antibodies against gliadin and/or endomysium and confirmed with histological findings of duodenum biopsy based on modified Marsh classification.
MPV and RDW levels were significantly higher in CD patients than control group (P<0.001 both). CD patients had significantly more often MS than control group (P=0.007). Patients with MS had significantly higher MPV and RDW compared to those without MS (P=0.004 vs. P=0.042 respectively).
These results suggest that CD patients are susceptible to increased platelet activation and increased MPV and RDW values that contribute to an increased risk of cardiovascular complications. The results may have clinical importance, because the parameters indicating inflammation in MS may be the early markers of developing cardiovascular events.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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