Endocrine Abstracts

Aim of the research: To study the histological structure of nonfunctional pituitary giant adenomas (NFPA)

Materials and methods: We observed 11 patients with giant NFPA, among them 5 male and 6 female, mean age 37.8. All patients were undergone surgical treatment by transsphenoidal access in Center of Endocrinology of MoH RU in neurosurgery department during 2014–2015 year.

All patients were undergone the spectrum of analyses, including endocrine status assessment, clinical, biochemical, hormonal (GH, LH, FSH, prolactin, TSH, testosterone and others), radiological (CT/MRI of Turkish saddle), and histological study. All patients have pituitary adenoma more than 5 cm.

Depending on the type of cells found on the histological study, patients with NFPA (chromophobic adenomas) were divided into 3 groups: 1st group – small cell (undifferentiated) chromophobic adenoma – 5 patients, 2nd group – large cell chromophobic adenoma – 6 patients, and 3rd group – oncocytoma (none).

Results: Preliminary analysis of the research showed that among the observed patients the most disposed to invasive total growth had patients of the 1st group with small cell histological structure of NFPA. Besides, this patients had more frequent tumor relapse in post-operative period – 3 patients (27.3%), had acute manifestation of the disease with general cerebral symptoms and neuroendocrine disturbances (secondary amenorrhea in female, potency and libido decrease in male, metabolic syndrome, visual disturbances and others). Two female patients aged 27.5 from the 1st group were undergone repeated selective pituitary adenomaectomy 3 times.

Conclusions: 1. Small cell NFPA have the most aggressive growth and tumor relapse. 2. Following research is necessary to study the markers of aggressiveness in all 3 groups.