Endocrine Abstracts

Aim: To study the frequency of growth hormone deficiency (GHD) in patients with nonfunctional pituitary tumors (NFPA).

Materials and methods: Over a period of 1.0 year, we studied in our department retrospective data of 33 patients with pituitary tumors in terms of CT/MRI imaging and detailed hormonal functional assessment – STH, IGF-1, LH, FSH, ACTH, prolactin, TSH, cortisol, thyroxine. From the patients are 11 – men and 12 women, mean age of patients 38.5 years.

Results: Microadenomas (<10 mm) were found in 11 patients, mesoadenomas (11–20 mm) in 11, macroadenomas (20–30 mm) in 11 patients.

Panhypopituitarism (PH) was noted in six persons (18.3%), PH with diabetes insipidus in 5 (15.2%), isolated GHD in 7 (21.2%), GHD and LH deficiency in 2 (6.0%), GHD and LH, FSH deficiency – in 11 patients (33.3%), GHD and LH, FSH, TSH deficiency in 2 (6.0%) Hypopituitarsin, that is, reduction in the levels of pituitary tropic hormones, such as, STH, LH and FSH was found in 75% (25 patients) large pituitary tumors with supra-, para- and infrasellar growth being registered in the patients.

Conclusions: The distribution of GHD in patients with NFPA has a lot of various disorders with combined deficiency of pituitary hormones levels.