Endocrine Abstracts

Introduction: Polycystic Ovary Syndrome is usually accompanied by metabolic changes such as carbohydrate and lipid metabolism disorders and obesity.

Aim: The aim of the study is to determine the impact of the deployment of body fat on selected biochemical parameters in women with Polycystic Ovarian Syndrome.

Materials and methods: The study included a group of 45 women with diagnosed Polycystic Ovarian Syndrome based on the 2003 Rotterdam criteria. In order to evaluate the distribution of body fat, the WHR (Waist-Hip Ratio) index was used. For the diagnosis of abdominal obesity we adopted the values ≥0.85 and <0.85 for gluteal-femoral obesity. A P value of <0.05 was considered to be significant.

Results: The group of women aged 18-40 years (16.4±5.6) entered the study. Significant differences were found between the group of women with gluteal-femoral obesity and the group of women with abdominal obesity in terms of average values of: HDL cholesterol (mg/dl) (71.08±14.84 vs. 48.95±8.48; P<0.0001), TG (mg/dl) (81.80±34.65 vs. 125.58±63.23; P=0.0054), HOMA index (1.97±1,64 vs. 3.07±1.18; P=0.0186), SHGB (nmol/l) (25.69±31,53 vs. 32.44±19.01; P=0.0008), free testosterone (pg/ml) (5.74±4.19 vs. 11.81±6.37; P=0.0004), and FAI index (4.02±3.31 vs. 8.16±4.00; P=0.0017).

Conclusion: Evaluation of body fat distribution seems to be useful in determining the risk of carbohydrate metabolism and lipid metabolism disorders as well as hyperandrogenemia in with Polycystic Ovarian Syndrome patients.