ECE2016 Eposter Presentations Endocrine tumours and neoplasia (68 abstracts)
Mechano growth factor (MGF) expression increased in secondary compared to primary foci in well neuroendocrine neoplasms
Krystallenia Alexandraki 1 , Anastasios Philippou 2 , Georgios Boutzios 1 , Panagiotis Moschouris 1 , James Karnezis 1 , Irini Theohari 3 , Michael Koutsilieris 2 , Ioanna Delladetsima 3 & Gregory Kaltsas 1
1Department of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece; 2Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 3First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).
Methods: We have used immunohistochemistry in 39 specimens of patients with NENs to show the expression status of MGF. Proliferation index ki-67 MIBI (%) was also evaluated. Specimens were divided in three subgroups: in 15 samples Ki-67 was ≤2%, in 15 2-20%, and in 9 >20%.
Results: Specimens from 8 gastric, 11 pancreatic, 2 appendiceals, 7 small intestine, 1 colic and 1 retrosigmoidal, 1 gallblader and 3 lung NENs, 2 undifferentiated unknown primary (UPO), 3 UPO were studied. No MGF staining was found in 19 specimens while cytoplasmatic staining was found in 20 specimens: focal staining was seen in 13 (65%) and diffuse in 6 (30%) and dot like in 1 (5%). Ki-67 and MGF expression were positively correlated in all the samples studied reaching a trend difference (r=0.29, P=0.07); the same correlation was seen only in the subgroup with ≤2% (r=0.48, P=0.07) but not in the other subgroups studied. MGF staining did not differ between primary and secondary foci in total sample population but staining was increased in secondary compared to primary foci in samples with ki-67 2–20%.
Conclusions: Our preliminary data indicate that MGF expression may have a limited role in the pathophysiology of NENs. Further studies will shed light to the exact role of MGF in NENs.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more