ECE2016 Eposter Presentations Endocrine Disruptors (6 abstracts)
Estimation of bisphenol A influence on obesity
Milica Medic Stojanoska 1 , Natasa Milosevic 2 , Vladimir Jaksic 3 , Bojan Vukovic 4 , Ivana Bajkin 1 , Andrijana Milankov 1 , Ivanka Percic 4 , Tijana Icin 1 , Branka Kovacev Zavisic 1 & Natasa Milic 2
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Medical Faculty University of Novi Sad, Novi Sad, Serbia; 2Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; 3Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; 4Emergency Center, Clinical Center of Vojvodina, Medical Faculty University of Novi Sad, Novi Sad, Serbia.
Introduction: Obesity is a global health problem. More than half (54%) of the adult population in Serbia and 58.5% of adult population in the north province, Vojvodina is obese or overweight. Hence, it is urgent to identify environmental factors which may contribute obesity. Bisphenol A (BPA) is one of the most extensively used chemical in production of food and beverage containers, epoxy resins, polycarbonate plastics and well known endocrine disruptor. The aim of this study is to determine the prevalence of BPA in urine samples in women in Vojvodina and to determine the association between BPA and obesity in women.
Method: The study was conducted in the Clinical Centre of Vojvodina and 103 women age between 18 and 55 were enrolled in the study and in their urine samples BPA was determined. Women were divided according to their body mass index (BMI) into two groups: N-normal weight (BMI<25 kg/m2) and O-obese group (BMI≥30 kg/m2).
Results: BPA was detected in 36% (37/103) women, 31% (16/52) in the N-group and 41% (21/51) in the O-group. The average concentration of BPA was 12.24±10.55 μg/g creatinine. The groups were additionally divided into two subgroups: BPA positive (BPA+) and BPA negative (BPA−). There was statistically significant linear correlation between BPA concentration in the urine sample and BMI (r=0.59, P=0.003) as well as between waist circumference and BMI (r=0.45, P=0.02) in the O-group. However, no statistical difference was found between BMI, waist circumference, or lipid status: HDL, LDL and total cholesterol among BPA+ and BPA- subgroups in both N- and O-group. The highest BPA concentrations were detected in younger women with highest BMI.
Conclusion: BPA is one of the most important factors which may contribute the increment of BMI and waist circumference, while HDL, LDL and total cholesterol may be associate factors which additionally influence obesity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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