ECE2016 Eposter Presentations Diabetes therapy (44 abstracts)
Effects of gender on IGF1 changes after initial basal insulin analog therapy in the type 2 diabetics
Soner Cander 1 , Ozen Oz Gul 2 , Pinar Sisman 3 , Nizameddin Koca 5 , Oguzhan Sitki Dizdar 3 , Taner Aydin 4 , Metin Guclu 1 , Emre Sarandol 6 & Canan Ersoy 2
1Bursa Yuksek Ihtisas Training and Research Hospital, Endocrinology and Metabolism, Bursa, Turkey; 2Uludag University Medical School, Endocrinology and Metabolism, Bursa, Turkey; 3Kayseri Training and Research Hospital, Internal Medicine, Kayseri, Turkey; 4Afyonkarahisar State Hospital, Endocrinology and Metabolism, Afyonkarahisar, Turkey; 5Bursa Yuksek Ihtisas Training and Research Hospital, Internal Medicine, Bursa, Turkey; 6Uludag University Medical School, Biochemistry, Bursa, Turkey.
Introduction: Serum IGF1 levels declined particularly with hyperglycemia in diabetic patients and lower IGF1 levels has been suggested to be associated with the development of diabetes. IGF1 levels appear to increase with the improvement in glycemic control in diabetic patients but do not reach normal levels. Also, it affected by gender; in this study we aimed to investigate effects of gender on IGF1 changes with basal insulin analogs.
Methods: The serum total IGF1 levels of the 62 insulin-native type 2 diabetic patients were studied before and after 12 weeks of the started treatment with basal insulin analogs. 42 patients using insulin detemir and 20 patients on insulin glargine were evaluated.
Results: Mean age of patients were 57.0±6.4 in the males (n=27) and 55.2±7.1 in the females (n=35). Changes in the IGF1 values are calculated as 0.5% decrease in the males and 2.1% increase in the females. Means IGF1 levels were 111.7±38.4 in the males and 111.5±47.5 before insulin therapy and were 107.6±35.9 in the males and 108.8±47.8 in the females at the end of the study. IGF1 change means were -4.1 and -2.6 in the males and females respectively.
Conclusion: In our study, it was observed that, while IGF1 levels remained unchanged or increased in the detemir groups, levels dropped at the level close to significance in the glargine group. The changes in the IGF1 level were found to be more evident in the males. The change differences between the male and female patients could be explained with the fact that BMI averages were different and that the daily variability in the serum IGF1 level was higher depending on the cyclic estrogen fluctuation in the females.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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