Endocrine Abstracts

Background: Pregnancy is a state of insulin resistance that can predict diabetes development in some women, and is associated with increased risk for neonate and for mother. Frequency of glucose intolerance may be increased in the follow-up years.

Aim: The aim of this study is to determine the presence of risk factors for type 2 diabetes and degree of glucose tolerance in population of pregnant women.

Materials and methods: The study included 77 healthy pregnant women in third trimester registered in centre for endocrinology CC Kragujevac that were tested, according to conducted 3 h OGTT with 100 g glucose (ADA criteria).

Results: Patients were average 30.8±4.7(19–41) years old. The frequency of risk factors were: obesity (3.9%), hypertension (5.2%), previous gestational diabetes mellitus (23.5%), smoking (23.4%), previous maternity body weight >4 kg (8.8%), positive family history for diabetes (27.3%). Prepregnancy BMI of participants was 22.0±2.6 kg/m², weight gain during pregnancy was obtained as 12.7±1.5 kg. It was shown that there was impact the number of risk factors on degree of glucose tolerance disorder (P=0.034), while most of patients had no risk factor (48%). Between 77 patients, the nine was with gestational diabetes mellitus and nine was with minimal disorder of glicoregulation. Including parameters of adverse outcome, it was shown that number of risk factors significantly impact on pregnancy outcome (P<0.005).

Conclusion: This research showed presence some of risk factors for type 2 diabetes in more than half of pregnant women. Women with glucose intolerance have higher risk for diabetes development.

Keywords: risk factor, diabetes, pregnancy