Endocrine Abstracts

Introduction: We report a case of diabetic papillopathy that demonstrated a resolution of optic disk swelling and rapid visual recovery when intravitreal ranibizumab was administered.

Case report: A 51-year-old male presented with acute painless visual loss in his right eye. His vision was 20/320 in the right eye and 20/50 in the left eye. Fundus examination of the right eye showed nonproliferative diabetic retinopathy with macular edema and a swollen optic disk. Fluorescein angiography showed dye leakage from the right optic disk. Optical coherent tomography revealed a significant increase in retinal nerve fiber-layer thickness. Magnetic resonance imaging of the brain was normal. The patient received a single intravitreal ranibizumab (0.5 mg) injection. Two weeks following injection, there was marked regression of the disk swelling and improvement of macular edema, with vision improving to 20/100. Three months following injection, there was complete resolution of the optic disk swelling. No further treatment was required.

Conclusions: A rapid improvement in vision was noted in our patient shortly after intravitreal injection of ranibizumab. Therefore, it may be that the intravitreal ranibizumab played a positive role in stabilizing and improving the patient’s optic nerve edema. However, the efficacy and safety of this management of diabetic papillopathy needs to be proven through further larger clinical studies.