ECE2016 Eposter Presentations Diabetes complications (55 abstracts)
Diabetes mellitus type-II related hypertension and cardiovascular diseases: involvement of impaired regulatory renin-angiotensin-aldosterone system
Shamila Shakoor 1 , Ghazala Kokab Raja 2 , Sarwat Jahan 3 , Abida Raza 4 , Maleeha Akram 1 , Syed Ali Raza Kazmi 5 , Sidrah Nazir 2 , Afzaal Ahmed Naseem 1 , Mazhar Qayyum 1 & Syed Shakeel Raza Rizvi 1
1Department of Zoology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, Pakistan; 2University Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, Pakistan; 3Department of Animal Sciences, Quaid-e-Azam University, Islamabad, Pakistan; 4Nuclear Medicine Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan; 5Aga Khan Health Centre, Rawalpindi, Pakistan.
Diabetes mellitus type-II (DM-2) is a metabolic disorder characterized by high blood glucose levels due to insulin resistance and relative insulin deficiency. DM-2 often leads to hypertension, a prolonged condition of elevated blood pressure (BP). Both hypertension and diabetes have a pathological role in causing cardiovascular diseases (CVDs). While renin-angiotensin-aldosterone system (RAAS) regulates arterial BP, any pathology in RAAS system may lead to hypertension and related CVDs. This study investigated the involvement of RAAS in causing DM-2-related hypertension and CVDs. Hundred male and female DM-2 hypertensive CVDs patients between ages 21 and 60 years and hundred healthy age-matched controls were examined. Using structured questionnaire, height, weight, BMI, BP, random glucose levels, blood samples, history, qualification, and socioeconomic status were gathered from both groups. Plasma aldosterone concentrations were determined by employing ELISA. Eighty-one patients were treated with either RAAS inhibitors (RAASi), non-RAASi or a combination of RAASi and non-RAASi, while 19 patients remained untreated. Of 20 patients treated with RAASi, 17 responded with aldosterone concentrations dropping to normal range, whereas 3 remained resistant to RAASi. Among 21 patients treated with non-RAASi, aldosterone concentrations fell to normal range in 13, while remained higher in 8 patients. Of 40 patients treated with both RAASi and non-RAASi, 31 responded with aldosterone concentrations falling within normal range, while 9 patients did not respond. Nine of 19 untreated patients had their aldosterone concentrations within normal range, whereas 10 patients exhibited significantly higher aldosterone concentrations. The majority of patients was married, fell in categories of overweight and obese, regularly exercised and followed diet plan, was illiterate or had primary level education, belonged to low and lower middle class socioeconomic status. In conclusion, the present study demonstrates that the over activity of RAAS may contribute in causing DM-2-related hypertension and consequent cardiovascular diseases in our population.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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