Endocrine Abstracts

Objective: To estimate the frequency of night time hypoglycemic reaction cases in daily monitoring of the glucose in interstitial fluid under the conditions of DM 1.

Materials and methods: The study of daily glucose dynamics was conducted with the use of the continuous glucose monitoring system made by the company Medtronik Minimed, USA. The study included 113 patients with DM 1. Patients ware divided into 2 groups: group 1 with hypoglycemic reaction cases (n=50), and group 2 without hypoglycemic reaction cases (n=63).

Results: The age of the patients in the group 1 was 29.49 (24.05; 36.18) years, in the group 2 it was 27.83 (21.13; 34.94) years (P>0.05). The period of the DM 1 in the group 1 was 9.07 (4.23;13.53), in the group 2 it was 7.18 (2.78; 13.62) years (P>0.05). The level of HbA1c in the group 1 was 8.20 (7.30; 9.40) %, in the group 2 it was 9.70 (8.40; 11.20] %, (P<0.001). BMI in the group 1 was 23.66 (21.97; 25.82) kg/m², in the group 2 it was 23.42 (21.45; 27.34) kg/m² (P>0.05). The daily dose of insulin in the group 1 was 0.72 (0.60; 0.87) IU/kg, in the group 2 it was 0.72 (0.56; 0.98) IU/kg (P>0.05). The frequency of night hypoglycemic reaction cases in the group 1 was 15% in males and 28% in females (P>0.05).

Between 23:00 and 03:00 the level of glucose in interstitial fluid in the group 1 was 7.80 (5.50; 10.60) mmol/l, it was 10.50 (8.80; 13.40) mmol/l, (P<0.001) in the group 2. Between 03:00 and 06:00 the level of glucose in interstitial fluid in group 1 was 8.20 (6.10; 11.10) mmol/l, it was 10.80 (8.70; 13.30) mmol/l (P<0.001) in the group 2.

Conclusion: 1. The frequency of nighttime hypoglycemic reaction cases doesn’t depend on sex, age, period of DM 1, daily dose of injected insulin.

2. The risk of night hypoglycemic reactions is higher in patients with the lower risk index of hypoglycemia that coincides with the minimum value of glycaemia at night and glycosylated hemoglobin.