Endocrine Abstracts

Background: Insulin resistance and diabetes mellitus are associated with decreased serum vitamin D level. Therefore, we evaluate the 25-OH-vitamin D in GDM. This study was performed to evaluate the serum vitamin D levels in GDM patients.

Methods: This study consisted of 38 patients with GDM who followed up in Haseki Training and Research Hospital’s Endocrinology outpatient clinic. GDM was diagnosed with 50 g (if postprandial 1 h >130–199 mg/dl) and then 100 g oral glucose tolerance test (OGTT) in 24–28 gestational weeks. The cut off criteria for GDM were as following at least two of results as; fasting blood glucose: 95 mg/dl, postprandial 1 h: 180 mg/dl, 2 h: 155 mg/dl, 3 h: 140 mg/dl. Serum vitamin D level and biochemical parameters were analyzed. Patients were divided into two groups as Group A (vitamin D <20 ng/ml) and Group B (>20 ng/ml).

Results: Mean BMI was 28.37±4.02 in Group A, 25.62±5.60 in Group B, (P: 0.033). Mean peripartum HbA1c was 5.51±0.54% in Group A and 5.04±0.48% in Group B, (P: 0.006). There was no any statistical difference in other biochemical parameters. Vitamin D was found to be negatively correlated with BMI (r: −0.377, P: 0.03) and peripartum HbA1c (r: −0.424, P: 0.014).

Conclusion: Vitamin D has a close relationship with BMI and peripartum HbA1c value. Moreover, decreased serum vitamin D level was correlates with higher BMI and HbA1c. Serum vitamin D level should be analyzed and followed up in patients during pregnancy.