Endocrine Abstracts

Background: Primary hyperaldosteronism is one of the major causes of secondary hypertension, with a prevalence rate of about 4–10% in the hypertensive population. Increased secretion of aldosterone usually comes from adrenal adenoma or their hyperplasia (uni or bilateral). Renines plasma levels are reduced as a result of the body’s efforts to curb renine-angiotensin system. It can also be associated with hypokalemi, but not always, more than 60% may not have hypokalemi.

Methods: The study included all of hypertensive patients hospitalized in the Internal Medicine for 1 year. These patients have undergone examinations such as glycemia, uremia, creatinin, liver tests, lipidograma, electrolytes, ECG, Echocardiography. In patients with resistant hypertension has been realized abdominal CT and in cases of suspicion of Conn adenoma is received plasma aldosterone and plasma renines activity.

Results: The total number of patients with hypertension was 399, age 59.47±13.64 years, of whom 162 (40.6%) were male and 237 (59.4%) women. Of these 141 (35.3%) were patients with resistant hypertension, and of these 35 (8.93%) resulted in the Conn Adenoma, confirmed by imaging and laboratory. Men were 23 (63.9%) patients and female 13 (36.1%). Of these 7 (19.4%) patients were presented for the first time with hypertension. 15 (41.7%) patients were hospitalized with hypertensive crisis. Average K⁺ in these patients was 3.89 mg/dl. (S.D. 0.47) Echocardiography in these patients shows TS 12.56 (S.D. 1:42), DTD-VM 49.61 (S.D. 5:59), TP 11:42 (S.D. 2.12).

Conclusions: Primary hyperaldosteronism is one of the most common causes of secondary hypertension. Hyperaldosteronism prevalence was about 9%, with a predominance in males about 64%. The initial diagnostic test to confirm the diagnosis is the aldosteron/renine ratio. Regarding getting in CT imaging, not always unilateral or bilateral hyperplasia or finding a formation of adrenal glands deals with primary hyperaldosteronism.