ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)
Relation between uric acid and lipid profiles in patients with type 2 diabetes
Eui-Hyun Kim 1 , Kwi-Hyun Bae 2 , Jae-Han Jeon 2 , Yeon-Kyung Choi 2 , Mi-Kyung Kim 3 , Hye-Soon Kim 3 , Keun-Gyu Park 2 & Hyun-Ae Seo 1
1Departments of Internal Medicine, Daegu Fatima Hospital, Daegu, Republic of Korea; 2Departments of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 3Departments of Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea.
Aims: High level of uric acid is known to associate with stroke, coronary artery disease and metabolic syndrome. Some epidemiologic studies suggested that high uric acid level is connected with dyslipidemia. However, this relationship was not examined in type 2 diabetic patients. This study was conducted to investigate the association between serum uric acid level and lipid profiles in type 2 diabetic patients.
Methods: A total of 972 type 2 diabetes patients were included in the present study. We measured height, body weight and blood pressure. Biochemical parameters including low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and total cholesterol (TC) were checked.
Result: The mean age of total subjects was 56.90±13.91 and men were 507 (52.2%). The mean body mass index (BMI) was 23.89±3.88. In the univariate analysis, TG and uric acid level was significantly positively correlated (r=0.155, P<0.001). HDL was significantly negatively associated with serum uric acid (r=−0.171, P<0.001). LDL and TC were not related with uric acid level. Multiple regression analyses were then performed by adjusting for age, sex and body mass index. The significantly positive association between TG and uric acid was retained (beta coefficient=0.131, P<0.001). The negative connection between HDL and uric acid was persisted (beta coefficient=−0.111, P=0.001).
Conclusion: In the present study, we found that serum uric acid level is significantly positively associated with TG, whereas it is significantly inversely associated with HDL in type 2 diabetic patients. Management for hyperuricemia may help to control dyslipidemia in patients with type 2 diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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