ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)
MiRNA-binding site polymorphisms of MODY genes associated with lipid profiles in Chinese patients with gestational diabetes mellitus
Xiaojing Wang 1 , Wei Li 1 , Jinsong Gao 2 , Liangkun Ma 2 , Ping Fan 1 , Min Nie 1 & Xinhua Xiao 1
1Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China; 2Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China.
Objective: Both MODY and GDM are characterized by pancreatic beta cell dysfunction. The study aimed to first investigate the associations between miR-SNPs of HNF4A, HNF1A and HNF1B genes and the GDM susceptibility and lipid profiles.
Methods: The software PolymiRTS were used to screen miR-SNPs. Genotyping of SNPs was performed with TaqMan allelic discrimination assays in 839 GDM patients and 900 controls. Multivariable logistic regression analysis and multiple linear regression adjusted for age were used to analyze the association.
Results: A total of three miR-SNPs rs6130615 (T/C, HNF4A), rs1169309 (T/G, HNF1A) and rs2688 (C/A, HNF1B) were selected, and the SNPs were located in miR-130a, miR-19a and miR-96 binding site respectively. The rs6130615, rs1169309 and rs2688 were not associated with GDM in Chinese Han women (P>0.05). We observed HNF1A rs1169309 genotype TT exhibited increased total cholesterol and LDL-c levels compared with wild genotype GG (P=0.003 and P=0.031). After adjustment for age and pre-BMI, the minor allele T rs1169309 SNP was found to be positively associated with total cholesterol (P<0.001) and LDL-c levels (P=0.010). We also found rs1169309 genotype TT+CT exhibited higher ApoA1 levels (P=0.029), and rs6130615 genotype TT carriers had higher ApoA1 levels than CT+CC carriers.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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