Endocrine Abstracts

The purpose: To investigate the prevalence and the relationship between cardiovascular complications (CVC) and risk factors (RF) in patients with essential hypertension (EH) and coronary heart disease (CHD) in combination with diabetes mellitus type 2 (DM-2).

Materials and methods: A retrospective analysis of case histories of 79 patients with cardiac profile (37 of them women, with an average patient age – 59.6±6.2 years) with hypertension stage II – III (hypertension duration - 8.9±3.2 years) and chronic forms of CHD (CHD duration – 9.7±2.4 years) with concomitant DM-2 (DM-2 duration – 6.8±1.6 years). Please observe the complications associated with diabetes, the level of psychosocial stress to conduct the survey on a scale Reader.

Results: In the studied group of heart rhythm disorder (arrhythmia extrasystolic and atrial fibrillation) were significantly more (P<0.05) occurred in women; males were more individuals with overweight (respectively 62% of males and 48% females). Atherogenic hyperlipidemia (AHL) was observed in 72% of women and 85% men. Myocardial infarction (MI) associated with the AHL and the violation of the compensation DM-2 (elevated glycosylated hemoglobin (HbA1c) in average 8.14±1.23%) and is more common in men than in women (18% and 8%). The connection AHL non-compliance with diet, irregular meals, and stress levels on the scale of the Reader (95% CI: 0.016 – 0.038; P<0.001). A negative correlation was between stress levels and body weight (r=−0.42); positive relationship – between stress, the incidence of MI and frequent infectious diseases (r=0.54). Manifestations of CVC were less pronounced in patients with an active lifestyle and in patients who had no bad habits (P=0.01).

Conclusions: The results of the analysis indicate that patients with hypertension and CHD with DM- 2 have more RF and CVC. Accompanying illnesses are very common in these patients, and modifiable risk factors, including hypertension, DM-2? Psychosocial stress should be considered as one of the main directions for the best results from the treatment and prevention of CVC.