Endocrine Abstracts

Introduction: Correction of Insulin resistance (IR) and dyslipidemic conditions of obese patients is important for the prevention of cardiovascular disease (CVD). The aim of our study is to determine the relationship between IR and non-high-density lipoprotein cholesterol (non-HDL-C) in obese patients.

Material and methods: 248 patients over the age of eighteen, non-pregnant, followed with a diagnosis of obesity but did not receive the treatment of metformin and statin are investigated retrospectively. Fasting glucose (FG), HbA1c, insulin, homeostasis model assessment of IR (HOMA-IR), LDL-C, triglycerides (TG), HDL-C, total cholesterol (TC) and non-HDL-C parameters of these patients were evaluated.

Results: Totally 248 patients (35 male (14.1%) – 213 female (85.9%) were included to study. When male and female patients are compared, significant differences were observed only for the parameters of HDL-C and TG (P<0.05). While it is found that HDL-C is higher in female group, TG is higher in male group. Intra-group comparisons reveal that there is a highly significant correlation between HOMA-IR and HDL-C (P<0.01). It is also observed that HOMA-IR and TG are highly correlated with each other among women (P<0.01). Among women it is also found that non-HDL-C is highly correlated both with FG and HbA1c (P<0.01).

Conclusion: When HOMA-IR as insulin resistance marker was found related with HDL-C and TG in women, the absence of this relation in men may be due to number of patients. However, the absence of correlation between HOMA-IR and non-HDL-C in male and female patients may be because of a more strong relationship between HOMA-IR and TG in early period. In addition to this, during this period the fact that non-HDL-C is highly correlated with both HbA1c and FG level may suggest that the importance of non-HDL-C in prediabetes and diabetes stages may increase.