Endocrine Abstracts

Introduction: The aim of the study was to asses frequency of the components of metabolic syndrome (MS) according to the criteria of the International Diabetes Federation (IDF) in patients with adrenal incidentaloma (AI) without hormonal activity.

Design: The study comprised of patients with AI without hormonal activity, confirmed in CT. The adrenal function was determined by measuring circadian rhythm of cortisol and/or dexametasone suppression test, aldosterone, plasma renin activity (PRA), DHEAS, androstenedione, metanephrines in urine. The physical examination of the patients included BMI, the waist circumference, blood pressure. The biochemical assays: OGTT, fasting insulin and lipids (total cholesterol, HDL, LDL, triglycerides). HOMA IR was also calculated. MS was diagnosed according to the IDF criteria.

Results: We examined 125 patients, mean age: 61.3±8.8 years, 72 (42.4%) were men. Tumor mean size: 27.6±15 mm. MS was diagnosed in 53 (42.4%) patients, 24 (19.2%) men. Abdominal obesity was diagnosed in 87 (69.6%) patients- 31 (24.8%) men. Total cholesterol was 218±49.7 mg/dl, HDL 59±21.1 mg/dl, LDL 134±44.1 mg/dl, triglycerides 116±60 mg/dl. 83 (66.6%) patients had dyslipidemia. In 99 (79.2%) patients hypertension was diagnosed, with the mean arterial systolic BP 131±15 mmHg, and diastolic PB 80±9 mmHg. Dysglycemia was observed in 62 (49.6%) patients aged: 62.9±7.5 years- 30 (24%) men. IFG was recognized in 24 (19.2%); IGT in 34 (27.6%), diabetes in 16 (13%) patients. Mean HOMA IR was 2.3±2.0 (mmol/l×uU/ml); in 78.4% (99 patients) we diagnosed insulin resistance (HOMA IR >1).

Conclusions: (1) In patients with AI without hormonal activity according to the IDF criteria MS was diagnosed in 42.4%.

(2) Patients with AI without hormonal activity are a risk group of prediabetes and diabetes.