ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Are there any differences between demographic characteristics, preoperative ultrasonographic findings, and cytological results of patients with thyroid tumors of uncertain malignant potential and papillary thyroid carcinoma of classical and non-encapsulated follicular variants?
Husniye Baser 1 , Oya Topaloglu 2 , Abbas Ali Tam 2 , Afra Alkan 3 , Aydan Kilicarslan 4 , Reyhan Ersoy 2 & Bekir Cakir 2
1Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Ankara, Turkey; 2Department of Endocrinology and Metabolism, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey; 3Department of Biostatistics, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey; 4Department of Pathology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.
Introduction: Thyroid tumors of uncertain malignant potential (TT-UMP) has been accepted as a subgroup of follicular-patterned thyroid tumors for which benignancy or malignancy cannot be assessed exactly. We aimed to evaluate demographic characteristics, ultrasound (US) findings, and cytological results of patients with TT-UMP and compare these findings with the classical variant of papillary thyroid carcinoma (CV-PTC) and non-encapsulated follicular variant of PTC (NEFV-PTC) patients, and also to evaluate the immunohistochemical characteristics of patients with TT-UMP.
Methods: Twenty-four patients with TT-UMP, 672 with CV-PTC, and 132 with NEFV-PTC were included to the study.
Results: Mean longitudinal nodule size and median nodule volume were higher in TT-UMP group compared to CV-PTC and NEFV-PTC groups (P<0.001 and P<0.001 for CV-PTC; P<0.001 and P=0.008 for NEFV-PTC). Presence of halo and peripheral vascularization were observed more frequently in TT-UMP group compared to CV-PTC group (P=0.002 and P=0.024). Nodule localization, texture, echogenicity, presence of microcalcification, and presence of macrocalcification were similar in TT-UMP and CV-PTC groups. US findings and cytological results were similar in TT-UMP and NEFV-PTC groups (all, P>0.05). Benign and follicular neoplasm/suspicious for follicular neoplasm cytological results were higher in TT-UMP group compared to CV-PTC group (P=0.030 and P=0.001). Median tumor size was higher in TT-UMP group than CV-PTC and NEFV-PTC groups (25 mm vs 6 mm, P<0.001 and 25 mm vs 14.4 mm, P=0.006, respectively). In TT-UMP group, positive expression of HBME-1, CK-19 and Gal-3 was found as 50%, 33.3%, and 25%, respectively.
Conclusion: This study demonstrated that patients with TT- UMP had higher nodule and tumor size compared to CV-PTC and NEFV-PTC patients. Moreover, we found that US features and cytological results were similar in NEFV-PTC and TT-UMP patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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