ECE2016 Eposter Presentations Thyroid cancer (81 abstracts)
Benefits of anti-thyroid peroxidase antibody and anti- thyroglobulin antibody for the prediction of differentiated thyroid cancer in Hashimoto thyroiditis
Sevilay Akalp Özmen 1 , Kenan Çadırcı 2 , Konca Altunkaynak 3 , İlknur Çalık 1 , Faruk Yıldız 2 , Esra Laloğlu 4 , Hakan Sevimli 2 , Hakan Gözc 2 , Abdulmuttalip Arslan 2 , Yasemin Kaya 5 , Havva Keskin 6 & Ayşe Çarlıoğlu 7
1Department of Pathology, Regional Education and Research Hospital, Erzurum, Turkey; 2Department of Internal Medicine, Regional Education and Research Hospital, Erzurum, Turkey; 3Department of Biochemistyr, Regional Education and Research Hospital, Erzurum, Turkey; 4Department of Biochemistyr, Atatürk University Faculty of Medicine, Erzurum, Turkey; 5Department of Internal Medicine, Ordu University Faculty of Medicine, Ordu, Turkey; 6Department of Internal Medicine, Göztepe Regional Education and Research Hospital, Istanbul, Turkey; 7Department of Endocrinology and Metabolism, Regional Education and Research Hospital, Erzurum, Turkey.
Purpose: The association between differentiated thyroid cancers and autoimmune thyroid diseases is well known. Therefore, we aimed to investigate the importance of thyroid peroxidase antibody (anti-TPO) and thyroglobulin antibody (Anti-Tg) in patients followed with the diagnosis of Hashimoto’s thyroiditis regarding the development of differentiated thyroid cancer.
Methods: A total of 56 patients including 22 Hashimoto’s thyroiditis patients operated on for nodules and with a histopathologic diagnosis of malignant differentiated thyroid cancer (17 papillary cancer, 5 follicular cancer) and 34 individuals with benign nodular goiter, and 35 healthy controls were included in the study. There were no statistically significant differences among the groups in terms of age and body mass index. Anti-thyroglobulin and anti-thyroid peroxidase antibody values within one month before surgery were taken. Association between postoperative histopathology and antibody levels was analyzed.
Results: In patients with Hashimoto’s thyroiditis, anti-TPO and anti-Tg were significantly different between benign and malignant groups (9.4±1.3 and 78.6±142.7) ve anti-Tg (19.0±5.3 and 421.9±1061.4) (P=0.026, P=0.013, respectively). There was a positive correlation between anti-TPO and anti-TG in the malignant group (P=0.01 r=0.386, P=0.03 r=0.259, respectively). In ROC analysis, TPO≥15 had 62.5% sensitivity and 100% specificity, anti TG ≥21 had 50% sensitivity and 100% specificity in predicting differentiated thyroid cancer in Hashimoto’s thyroiditis.
Conclusion: It appears that preoperative high anti-TPO and anti-Tg levels are a useful indicator to predict differentiated thyroid cancers.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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