ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Glomerular filtration rate in euthyroid Hashimoto’s patients
Yasemin Coskun Firat 1 , Ozge Timur 2 , Can Sevinc 1 , Faruk Yildiz 2 , Emine Kartal Baykan 3 , Unsal Aydin 3 , Mehmet Emin Budak 2 , Hakan Gozcu 2 , Abdulmuttalip Arslan 2 , Hakan Sevimli 2 & Ayse Carlioglu 3
1Regional Training and Research Hospital, Department of Nephrology, Erzurum, Turkey; 2Regional Training and Research Hospital, Department of Internal Medicine, Erzurum, Turkey; 3Regional Training and Research Hospital, Department of Endocrinology, Erzurum, Turkey.
Thyroid hormones influence renal development, kidney structure, renal hemodynamics, glomerular filtration rate, the function of many transport systems along the nephron and sodium and water homeostasis. Patients with hypothryoidism can have clinically important reductions in glomerular filtration rate (GFR). 41 patients (mean age 31.5±11 years) newly diagnosed as Hashimoto thyroiditis with presence of high thyroid autoantibodies with gland heterogenity in ultrasound and age-matched 30 healthy subjects attending to Erzurum Research and Training Hospital Endocrine outpatient clinic were included to the study. GFR of the patients and control groups were calculated using 4 variable MDRD Formula. GFR>125 ml/dk considered as hyperfiltration. Pearson correlation test was made to determine the correlation between FT3, FT4, TSH, anti TPO, anti TG and GFR. There was no significant correlation between FT3, FT4 and GFR. (r=0.12, P=0.33). There was positive correlation between anti TPO (r=0.32, P=0.02), anti TG (r=0.29, P=0.03) and GFR. GFR decreases with age and BMI. In our study GFR was found decreased independent from age, gender and BMI. Although our study is one of the first studies to examine the association between GFR and thyroid autoimmunity was insufficient in explaining the mechanism.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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