ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Conjunctival impression cytology is worsened in Hashimoto’s thyroiditis without thyroid associated ophthalmopathy
Mustafa Altay 1 , Tugba Sahin 2 , Zennure Yildiz 2 , Gulcin Simsek 3 , Mehmet Citirik 4 , Ihsan Ates 5 & Muharrem Bitiren 3
1Department of Endocrinology and Metabolism, Keçiören Training and Research Hospital, Ankara, Turkey; 2Department of Ophtalmology, Keçiören Training and Research Hospital, Ankara, Turkey; 3Department of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey; 4SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; 5Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Introduction: We aimed to investigate the conjunctival surface changes in Hashimoto’s thyroiditis (HT) patients and controls comparatively, and search the correlation of these changes with thyroid functions and thyroid autoantibody level in patients without thyroid associated ophthalmopathy (TAO).
Methods: A total of 25 patients with HT and 33 healthy individuals were enrolled in the study. Serum TSH, fT4 and fT3 level, and anti-thyroid peroxidase (anti-TPO) levels were studied and then, they had thyroid ultrasonography. Following the routine eye examinations, Schirmer test was applied to determine the dry eye and specimen were taken from the temporal bulbar conjunctiva with a cellulose acetate membrane filter for the conjunctival impression cytology.
Results: We found; 1. Grade 2–3 conjunctival squamous metaplasia was more frequently seen in HT than controls (48% vs 6.1%, P < 0.001). 2. Patients who have Grade 3 changes had increased serum TSH and anti-TPO, decreased fT4 levels. 3. Serum Anti-TPO level and BMI were detected as independent predictors of worsening at the conjunctival impression cytology.
Conclusions: In conclusion, we showed for the first time that conjunctiva was affected in HT distinct from TAO and anti-TPO levels and obesity were possible triggering factors on this process.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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